Morphometric assessment of the effects of monosodium glutamate on the carotid sinus wall: an experimental study

The increase in global burden of stroke is hard to overestimate. Every year it continues be a leading cause mortality worldwide. Extracranial pathology the carotid arteries major underlying reason stroke. Given role alimentary factors development atherosclerosis arteries, possible influence food additives on sinus structure special interest. Monosodium glutamate one most common that allowed for consumption many countries due being considered relatively safe. Recent scientific research however points towards adverse effects monosodium living organism. aim this study was analyze qualitative and quantitative parameters structural organization white male albino rats under normal conditions, setting oral after its withdrawal. Carotid sinuses 30 had been daily consuming 10 mg/kg 4 or 8 weeks with subsequent withdrawal 2 were subjected analysis at different time-points experiment. data obtained compared results morphologic morphometric 9 control group. For analysis, following considered: intima thickness, media adventitia diameters arterioles, venules capillaries vasa vasorum. Summarizing results, worth noting that, duration experiment, steady thickness all layers vascular wall, but especially adventitia, observed At same time, diameter arterioles located decreasing, while demonstrated invariable their lumen diameter. After withdrawal, continued increase, somewhat decreased, probably fibrosis dystrophy. tendency narrowing arterioles’ widening persisted least despite discontinuation glutamate. Therefore, systematic may lead impairment organization, particularly endothelial proliferation, fibrotic dystrophic changes media, thickening as well microcirculatory vessels damage, continue persist additive